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The classical concept of thyroid hormone regulation is based on a hypothalamic regulation of TSH secretion, but a peripheral regulation of thyroid hormone production may be also of importance. We evaluated the peripheral effect of TSH on human thyroid cell function in vitro. Cultures were established from specimens of healthy and thyroidectomized thyroid tissue obtained from multinodular goiters. Thyrotropic and/or antithyrotropic factors in serum were determined by reverse hemolytic plaque assays. TSH stimulated the conversion of thyroxine into triiodothyronine in thyroid cell cultures of multinodular goiters, which was directly correlated with the increase in thyroxine deiodination. The stimulation was more marked in patients who had been thyroidectomized. The results of this study indicate that the peripheral effect of TSH on thyroid hormone production is independent of the control by hypothalamic TSH. It is suggested that similar peripheral effects could be responsible for some of the clinical disorders observed in hyperthyroidism.Q:
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I am new to google app engine. Please help me to make some demo or application,
i want to use localhost but website must be on google app engine.
if one has website what should be on app engine?
If one create many application on app engine, how to install and deploy?
A:
you need to create your own server first eea19f52d2
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May 31, 2022